BDBM50451549 CHEMBL4207737
SMILES COc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F
InChI Key InChIKey=VFNHDIWHQGVWLL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50451549
Affinity DataEC50: 225nMAssay Description:Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mob...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at human M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as maximal response to ACh by calcium ...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
Affinity DataEC50: 56nMAssay Description:Positive allosteric modulator activity at human M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylchol...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Positive allosteric modulator activity at rat M4 receptor expressed in CHO cells co-expressing Gqi5 in presence of EC20 concentration of acetylcholin...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP34A in human liver microsomes using midazolam as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP34A in human hepatocyte using midazolam as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr ...More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP2B6 in human hepatocyte using bupropion as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr ...More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP1A2 in human hepatocyte using phenacetin as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of hERG cardiac ion channelMore data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at rat M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as maximal response to ACh by calcium mo...More data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Positive allosteric modulation of Gqi5-fused human M4 AChR assessed as increase in acetylcholine-induced calcium mobilizationMore data for this Ligand-Target Pair