BDBM50452154 CHEMBL4205266

SMILES CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)-c2ccc3nc(NC(C)=O)cn3c2)CC1

InChI Key InChIKey=JEDLVRSMLXMTLH-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452154   

TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452154(CHEMBL4205266)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452154(CHEMBL4205266)
Affinity DataIC50: 11nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452154(CHEMBL4205266)
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50452154(CHEMBL4205266)
Affinity DataEC50:  130nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed