BDBM50452609 CHEMBL4206099

SMILES CC[C@@H](NC(=O)N1C\C(NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)=N\Oc1ccccc1)c1ccc(C(O)=O)c(N)c1

InChI Key InChIKey=LHASZEBEQGPCFM-CJFMBICVSA-N

Data  1 IC50  1 Koff

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50452609   

TargetChymase(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetChymase(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataKon:  2.10E-8M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 12.5 to 200 nM by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB