BDBM50453197 CHEMBL4208701

SMILES N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCOCC4)cc3)c3ncn(C4CCCC4)c3n2)CC1

InChI Key InChIKey=RBJJYZNTQRAUAB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50453197   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Palack£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50453197BDBM50453197(CHEMBL4208701)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Palack£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50453197BDBM50453197(CHEMBL4208701)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Palack£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50453197BDBM50453197(CHEMBL4208701)
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant wild type human FLT3 (R571 to S993 residues) expressed in Sf9 insect cells using poly (Ala,Glu,Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed