BDBM50454187 CHEMBL5272590

SMILES C=CC(=O)Nc1ccc2ncc(NC(=O)Nc3ccccc3)nc2c1

InChI Key InChIKey=KJKCOOWPRZTMQC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50454187   

TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50454187(CHEMBL5272590)
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using TK as substrate incubated for 1 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50454187(CHEMBL5272590)
Affinity DataIC50: 25nMAssay Description:Inhibition of EGFR (unknown origin) using TK as substrate incubated for 30 min in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50454187(CHEMBL5272590)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) using TK as substrate incubated for 1 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed