BDBM504550 (S)-5-(Benzo[d]oxazol-2-yl)-1-(2-fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-2-one::US11066396, Example 22

SMILES Fc1cc(ccc1N1[C@@H](CCC1=O)c1nc2ccccc2o1)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=NAHXAFPFZQPKFV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504550   

TargetHistone deacetylase 6(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504550((S)-5-(Benzo[d]oxazol-2-yl)-1-(2-fluoro-4-(5-(trif...)
Affinity DataIC50: 4.70nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504550((S)-5-(Benzo[d]oxazol-2-yl)-1-(2-fluoro-4-(5-(trif...)
Affinity DataIC50: 32nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504550((S)-5-(Benzo[d]oxazol-2-yl)-1-(2-fluoro-4-(5-(trif...)
Affinity DataIC50: 350nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent