BDBM50455149 CHEMBL4206427

SMILES CC1(C)CN[C@@H]([C@@H](Oc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)O1)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=NASMQJIAKMAEMO-MSOLQXFVSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50455149   

TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50455149(CHEMBL4206427)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -65 mV holding potential by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50455149(CHEMBL4206427)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at recombinant human Nav1.6 assessed as reduction in channel current by barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50455149(CHEMBL4206427)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in channel current at -60 mV holding potential after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50455149(CHEMBL4206427)
Affinity DataIC50:  6.00E+3nMAssay Description:Antagonist activity at recombinant human Nav1.5 expressed in HEK293 cells assessed as reduction in channel current at -50 mV holding potential after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50455149(CHEMBL4206427)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at recombinant human Nav1.2 assessed as reduction in channel current by barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed