BDBM50455959 CHEMBL5281903

SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCN1CCOCC1

InChI Key InChIKey=WBKHQQZRHCECKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50455959   

TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50455959(CHEMBL5281903)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human EGFR using 5-FAM-EEPLYWSFPAKKKCONH2 as substrate incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50455959(CHEMBL5281903)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human EGFR L858R mutant using 5-FAM-EEPLYWSFPAKKKCONH2 as substrate incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50455959(CHEMBL5281903)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human EGFR d746-750 mutant using 5-FAM-EEPLYWSFPAKKKCONH2 as substrate incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
School of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50455959(CHEMBL5281903)
Affinity DataIC50: 209nMAssay Description:Inhibition of human EGFR L858R/T790M mutant using 5-FAM-EEPLYWSFPAKKKCONH2 as substrate incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed