BDBM50457305 CHEMBL4214523

SMILES CNC(=O)c1ccc(OC(C)C)c(Nc2nccc(n2)-c2cc3c(NC[C@]3(C)CO)c(c2)C#N)c1

InChI Key InChIKey=MTYLWTUJDYRYMS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457305   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457305(CHEMBL4214523)Copy SMILESCopy InChI

Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K14 autophosphorylation after 1 hr by Alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Amri

Curated by ChEMBL

LigandBDBM50457305(CHEMBL4214523)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of MAP3K14 in human L363 assessed as decrease in IKKalpha phosphorylation level after 2 hrs by sandwich immuno assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/16/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL