BDBM50457592 CHEMBL4204742

SMILES Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)C=C(CF)OC(N)=N1)C#N

InChI Key InChIKey=JJMGWWLDRBWVOL-FQEVSTJZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50457592   

TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50457592(CHEMBL4204742)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant BACE1 (43 to 545 residues) expressed in Escherichia coli BL21(DE3) using APP Swedish Lys-Met/Asn-Leu mutant as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50457592(CHEMBL4204742)
Affinity DataIC50:  67nMAssay Description:Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50457592(CHEMBL4204742)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells transfected with human wild type beta-APP assessed as reduction in amyloid beta (1 to 40) levels after 24 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed