BDBM50457655 CHEMBL4213787

SMILES Clc1ccc(-c2nc(cs2)C(=O)NNC(=O)c2ccccn2)c(Cl)c1

InChI Key InChIKey=BMBIKZHGTPMMMM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50457655   

TargetTumor necrosis factor receptor superfamily member 1A(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50:  770nMAssay Description:Inhibition of TNFR in TLR null HEK-blue cells assessed as decrease in TNFalpha-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50:  370nMAssay Description:Inhibition of PKC in TLR null HEK-blue cells assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50:  260nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterleukin-1 receptor type 1(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50:  720nMAssay Description:Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50:  590nMAssay Description:Inhibition of PKC in HEK-blue cells expressing human TLR7 assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed