BDBM50458598 CHEMBL4215807::US10752615, Compound 25

SMILES C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccns3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2

InChI Key InChIKey=BGHWKOZZYSOJOH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50458598   

TargetTyrosine-protein kinase TXK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 0.590nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase TXK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of TXK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BTK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 0.700nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ITK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 1.62nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 3.16nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458598BDBM50458598(CHEMBL4215807 | US10752615, Compound 25)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TEC (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed