BDBM50458599 CHEMBL4218914::US10752615, Compound 27

SMILES C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN4CCOCC4)ccc31)C2

InChI Key InChIKey=PWBFGGSRGAQQKP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50458599   

TargetTyrosine-protein kinase TXK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of TXK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 0.670nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ITK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 1.52nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 2.27nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of TEC (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 2.59nMAssay Description:The in vitro kinase assays were performed at Nanosyn (Santa Clara, Calif.) utilizing microfluidic detection technology. The test compounds were seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Gb005

US Patent
LigandChemical structure of BindingDB Monomer ID 50458599BDBM50458599(CHEMBL4218914 | US10752615, Compound 27)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of BTK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed