BDBM50459265 CHEMBL4205274

SMILES CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccc(I)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O

InChI Key InChIKey=FAZKACLBWZFQSM-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50459265   

TargetUrotensin-2 receptor(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50459265(CHEMBL4205274)
Affinity DataIC50: 4nMAssay Description:Displacement of [Na125I]-synthetic URP from human UT receptor expressed in HEK293 cell membranes incubated for 2 hrs by gamma-countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50459265(CHEMBL4205274)
Affinity DataEC50:  7.10nMAssay Description:Agonist activity at human UT receptor expressed in HEK293 cells co-expressing Gq-polycistronic BRET biosensor assessed as induction of Gq activation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Rat)
Laval University

Curated by ChEMBL
LigandPNGBDBM50459265(CHEMBL4205274)
Affinity DataEC50:  10nMAssay Description:Agonist activity at UT receptor in Sprague-Dawley rat thoracic aortic ring assessed as induction of contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50459265(CHEMBL4205274)
Affinity DataEC50:  36nMAssay Description:Agonist activity at human UT receptor expressed in HEK293 cells co-expressing G12-polycistronic BRET biosensor assessed as induction of G12 activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50459265(CHEMBL4205274)
Affinity DataEC50:  191nMAssay Description:Agonist activity at human UT receptor expressed in HEK293 cells co-expressing beta-arrestin1-polycistronic BRET biosensor assessed as induction of be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed