BDBM50459479 CHEMBL1740406

SMILES Cc1cc2N(Cc3ccccc3)C3=NCCCN3c2cc1C

InChI Key InChIKey=PZYNAAWDMPCHOX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459479   

TargetSon of sevenless homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50459479(CHEMBL1740406)
Affinity DataEC50:  2.32E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK1/2 level measured for 30 mins by Western blot an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50459479(CHEMBL1740406)
Affinity DataEC50:  2.32E+4nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed