BDBM50459559 CHEMBL4203192

SMILES Nc1nc(Nc2cc(C#N)n(c2)C2CC2)nc(n1)-c1cccc(c1CO)-n1ccc2cc(cc(F)c2c1=O)C1CC1

InChI Key InChIKey=PZZZRQOJGNDQJN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50459559   

TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50459559(CHEMBL4203192)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of N-terminal DYKDDDDK tagged biotinylated unactivated human recombinant BTK using FITC-labeled Srctide peptide substrate by by mobility s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50459559(CHEMBL4203192)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of N-terminal DYKDDDDK tagged biotinylated activated human recombinant BTK using FITC-labeled Srctide peptide substrate by mobility shift ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Carna Biosciences

Curated by ChEMBL
LigandPNGBDBM50459559(CHEMBL4203192)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed