BDBM50459691 CHEMBL4215663::US12006283, Example 16

SMILES COc1cc(NCc2ccc(cc2)C#N)ccc1C(=O)C(C)c1ccccc1F

InChI Key InChIKey=DXTLYFHTIAJXLP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50459691   

TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459691(CHEMBL4215663 | US12006283, Example 16)
Affinity DataIC50: 5.28E+3nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50459691(CHEMBL4215663 | US12006283, Example 16)
Affinity DataIC50: 5.28E+3nMAssay Description:The experiment was performed in order to evaluate inhibitory activity against angiogenesis of the compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
US Patent