BDBM50460203 CHEMBL4229108

SMILES COc1ccccc1C(=O)O\N=C(/C)c1nc2ccccc2o1

InChI Key InChIKey=GELNZECOIXMKEF-YBFXNURJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50460203   

TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460203(CHEMBL4229108)
Affinity DataIC50:  1.52E+4nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 1 to 5 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460203(CHEMBL4229108)
Affinity DataIC50:  2.59E+4nMAssay Description:Inhibition of human TLR4 signaling expressed in HEK-Blue cells co-expressing MD2/CD14 assessed as reduction in LPS-induced NF-kappaB activation-media...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50460203(CHEMBL4229108)
Affinity DataIC50:  3.95E+4nMAssay Description:Inhibition of NLRP3 inflammasome in human THP1 cells assessed as reduction in MSU-induced IL-1beta production preincubated for 1 hr followed by MSU s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed