BDBM50460693 CHEMBL4226562

SMILES COc1cc(ccc1Nc1ncc(Cl)c(NC(=O)Nc2cccc(NC(=O)C=C)c2)n1)N1CCC(CC1)N1CCOCC1

InChI Key InChIKey=GOKFAZOSPCHSOH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50460693   

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460693(CHEMBL4226562)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460693(CHEMBL4226562)
Affinity DataIC50: 131nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460693(CHEMBL4226562)
Affinity DataIC50: 641nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology Co. Itd.

Curated by ChEMBL
LigandPNGBDBM50460693(CHEMBL4226562)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed