BDBM50460935 CHEMBL4224859

SMILES CC(C)Nc1ccc2cnn(-c3cncc(n3)-c3ccc(C(O)=O)c(F)c3)c2c1

InChI Key InChIKey=GIMGRIKBHQXFGE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460935   

TargetCasein kinase II subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460935(CHEMBL4224859)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50460935(CHEMBL4224859)
Affinity DataIC50: 28nMAssay Description:Inhibition of Nano Luc-fused PIM3 (unknown origin) expressed in HEK293 cells using NanoGlo as substrate by NanoBRET In-cell target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460935(CHEMBL4224859)
Affinity DataIC50: 180nMAssay Description:Inhibition of CK2alpha in human HCT116 or human DLD1 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460935(CHEMBL4224859)
Affinity DataIC50: 220nMAssay Description:Inhibition of human PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460935(CHEMBL4224859)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed