BDBM50463047 CHEMBL1794748

SMILES OC(=O)c1nnsc1Sc1ccc(Cl)cc1

InChI Key InChIKey=NDYKFFAREALEPX-UHFFFAOYSA-N

Data  2 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50463047   

Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataKi:  4.50E+3nMAssay Description:Non competitive inhibition of mouse glycolate oxidase in hyperoxaluric-Agxt knockdown mouse primary hepatocyte assessed as reduction in oxalate produ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataKi:  2.03E+4nMAssay Description:Inhibition of mouse N-terminal His-tagged glycolate oxidase expressed in BL21(DE3) Escherichia coli using glycolate as substrate by Cornish-Bowden pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  3.30E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 48 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant HAO1 assessed as detecting hydrogen peroxide using glycolic acid as substrate preincubated for 30 min followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by sulfonated DCIP dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  3.40E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 72 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  2.53E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 24 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of mouse N-terminal His-tagged glycolate oxidase expressed in BL21(DE3) Escherichia coli using glycolate as substrate by Cornish-Bowden pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed