BDBM50463560 CHEMBL4249247

SMILES CC(C)(O)C1CCc2c(C1)[nH]c1c(ccc(-c3cccc(CNC(=O)C=C)c3)c21)C(N)=O

InChI Key InChIKey=CRSVKQFFZPGSSV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50463560   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50463560(CHEMBL4249247)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant human full-length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system using fluorescence-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50463560(CHEMBL4249247)
Affinity DataIC50: 200nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in intracellular calcium level incubated for 1 hr measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed