BDBM50468397 CHEMBL4276742::US11834432, Compound S10

SMILES CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)N4C[C@H](C)N[C@H](C)C4)c3)ccc12

InChI Key InChIKey=CHZKEAYTNKCUEF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50468397   

TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA based spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 10nMAssay Description:1. Enzyme reaction substrate μPoly(Glu,Tyr)4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 10nMAssay Description:Inhibition of human VEGFR2 in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468397(CHEMBL4276742 | US11834432, Compound S10)
Affinity DataIC50: 15nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed