BDBM50469203 CHEMBL4289810

SMILES CN1CCN(CCNc2nccc(n2)C2(CC2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)CC1

InChI Key InChIKey=CZUGFURKAUPQAE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50469203   

TargetSerine/threonine-protein kinase B-raf(Human)
University of Science & Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50:  20nMAssay Description:Inhibition of BRAF (unknown origin) using full length His6-tagged MEK1 as substrate after 20 mins in presence of 33P-gamma-ATP by hotspot kinase assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
University of Science & Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50:  18nMAssay Description:Inhibition of CRAF (unknown origin) after 20 mins in presence of 33P-gamma-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
University of Science & Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50:  30nMAssay Description:Inhibition of ARAF (unknown origin) after 20 mins in presence of 33P-gamma-ATP by hotspot kinaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Science & Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50:  13nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Science & Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length human GST-tagged BRAF V600E mutant (AA416 to 766 residues (unknown origin) using full length His6-tagged MEK1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed