BDBM50473686 CHEMBL433314

SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](CO)C(=O)NO)C(C)(C)C

InChI Key InChIKey=MOODLLAARDEUNJ-GRYCIOLGSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50473686   

Target72 kDa type IV collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.300nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  9.80nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataKi:  13nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetTumor necrosis factor(Human)
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50473686(CHEMBL433314)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed