BDBM50477021 CHEMBL236596

SMILES CCC[C@H](NC(=O)[C@@H](O)C(C)(C)C)C(=O)Nc1ncc(s1)C(C)CCCC(C)(C)OC

InChI Key InChIKey=URHOPXMUZHWVON-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50477021   

TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477021(CHEMBL236596)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477021(CHEMBL236596)
Affinity DataIC50: 13nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed