BDBM50477069 CHEMBL240068

SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1ncc(s1)C(C)NCc1ccccc1

InChI Key InChIKey=ROTMTHJHXSDEQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50477069   

TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477069(CHEMBL240068)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase activity in human H4 cells transfected with APP695 mutant assessed as beta amyloid(1-40) production by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50477069(CHEMBL240068)
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase C100Flag cleavaging activity in HeLa cell membranes assessed as M-amyloid beta-40 production by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed