BDBM50478157 Carbovir-Triphosphate

SMILES Nc1nc2c(c(=O)[nH]1)NCN2[C@H]1C=C[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C1

InChI Key InChIKey=UJVHRCJTPIOZRB-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50478157   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50478157BDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50: 680nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50478157BDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50: 900nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50478157BDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50478157BDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50478157BDBM50478157(Carbovir-Triphosphate)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed