BDBM50480124 CHEMBL496202

SMILES CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cc(ccc1F)C(F)(F)F

InChI Key InChIKey=FDDWGCNOHJMCBF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50480124   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480124(CHEMBL496202)
Affinity DataIC50:  12nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480124(CHEMBL496202)
Affinity DataIC50:  3.06E+3nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed