BDBM50481570 CHEMBL589505

SMILES COc1ccc(cc1)N1CCN(CC1(C)C)c1nc(Nc2cc(ccc2C)C(C)(C)C)cc(n1)C(=O)NCC1CCCO1

InChI Key InChIKey=HAWNIXNRIWUSFJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50481570   

TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50481570(CHEMBL589505)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of gamma-secretase-mediated NotchdeltaE cleavage in human HeLa cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed