BDBM50482052 CHEMBL1093400

SMILES Clc1ccc(cc1)C1Cc2n[nH]cc2CN1S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=ZRCZGEIHIFDAPM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50482052   

TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482052(CHEMBL1093400)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assessed as amyloid beta40 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482052(CHEMBL1093400)
Affinity DataIC50: 311nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human IMR-32 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482052(CHEMBL1093400)
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed