BDBM50485953 CHEMBL2180356

SMILES COc1cc(\C=C2/O[C@H](C)CN3[C@H](CON=C23)c2cc(F)cc(F)c2)ccc1-n1cnc(C)c1

InChI Key InChIKey=ODEIUBHPOCSQNG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50485953   

TargetPresenilin-1(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50485953(CHEMBL2180356)
Affinity DataIC50: 16nMAssay Description:Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed