BDBM50485969 CHEMBL2180378

SMILES COc1cc(\C=C2/CCCN3C2=NOCC3(CO)c2ccc(F)cc2)ccc1-n1cnc(C)c1

InChI Key InChIKey=JZXNBTGPYQFHEX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50485969   

TargetPresenilin-1(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50485969(CHEMBL2180378)
Affinity DataIC50: 1.33E+4nMAssay Description:Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed