BDBM50485976 CHEMBL2180357

SMILES COc1cc(\C=C2/O[C@@H](C)CN3[C@H](CON=C23)c2cc(F)c(F)c(F)c2)ccc1-n1cnc(C)c1

InChI Key InChIKey=DHCFQUMNNPDWHH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50485976   

TargetPresenilin-1(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50485976(CHEMBL2180357)
Affinity DataIC50: 46nMAssay Description:Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed