BDBM50485978 CHEMBL2180370

SMILES CCc1csc(C[C@H]2CON=C3N2CCC\C3=C/c2ccc(c(OC)c2)-n2cnc(C)c2)n1

InChI Key InChIKey=YSQHNBXDPUPJFX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50485978   

TargetPresenilin-1(Human)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50485978(CHEMBL2180370)
Affinity DataIC50: 6.40E+3nMAssay Description:Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed