BDBM50489454 CHEMBL2322338

SMILES CCc1nn2c(O)cc(nc2c1Cc1cccc(Cl)c1Cl)-c1ccncc1

InChI Key InChIKey=CIPIRSWYLQEXLK-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50489454   

LigandPNGBDBM50489454(CHEMBL2322338)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50489454(CHEMBL2322338)
Affinity DataEC50: <3.16E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as reduction of AKT phosphorylation at Ser 473More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50489454(CHEMBL2322338)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50489454(CHEMBL2322338)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50489454(CHEMBL2322338)
Affinity DataIC50:  158nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50489454(CHEMBL2322338)
Affinity DataIC50:  398nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed