BDBM50491226 CHEMBL2380443

SMILES COc1cccc(c1)-c1cccc(c1)C1(C)OCCC(N)=N1

InChI Key InChIKey=KQMBMKYLPGWKDZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50491226   

TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50491226(CHEMBL2380443)
Affinity DataIC50: 630nMAssay Description:Inhibition of BACE1-mediated soluble APPbeta release in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50491226(CHEMBL2380443)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1 (1-460) using CEVNLDAEFK as substrate preincubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed