BDBM50496624 CHEMBL3134497

SMILES C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(=O)c1ccc(OCC#C)cc1)Cc1ccccc1)C(=O)N[C@@H]1N=C(C2CCCCC2)c2ccccc2NC1=O

InChI Key InChIKey=HBXFXJVDXXQNMN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50496624   

TargetPresenilin-1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50496624(CHEMBL3134497)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of gamma-secretase (unknown origin) using APP substrate assessed as amyloid-beta40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50496624(CHEMBL3134497)
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma-secretase (unknown origin) using Notch1 substrate assessed as Notch1-NICD productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50496624(CHEMBL3134497)
Affinity DataIC50: 20nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in CHO cells transfected with APP assessed as amyloid-beta42 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed