BDBM50497559 CHEMBL3344072

SMILES CC(C)(C)c1ccc(-c2nc3c(sc4ccccc43)c(=O)[nH]2)cc1

InChI Key InChIKey=GERFIVKNGYXTHK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50497559   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497559BDBM50497559(CHEMBL3344072)
Affinity DataIC50: 21nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497559BDBM50497559(CHEMBL3344072)
Affinity DataIC50: 29nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497559BDBM50497559(CHEMBL3344072)
Affinity DataIC50: 832nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed