BDBM50498976 CHEMBL3736183

SMILES CO[C@H]1CCN(C[C@H]1F)c1nccc(Nc2cc3n(C(C)C)c(C)nc3cn2)n1

InChI Key InChIKey=WBAMFNDJQOEJFN-PBHICJAKSA-N

Data  7 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50498976   

TargetEpidermal growth factor receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  2.70nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins followed by addition of substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as peptide substrate preincu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  41nMAssay Description:Inhibition of human EGFR T790M/del (746 to 750 residues) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  608nMAssay Description:Inhibition of human EGFR L858R mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 peptide as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  896nMAssay Description:Inhibition of wild type human EGFR assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  1.08E+3nMAssay Description:Inhibition of human wild type EGFR using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins followed by addition of substrate measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human EGFR del (746 to 750) mutant assessed as apparent inhibition constant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataIC50:  250nMAssay Description:Inhibition of EGFR phosphorylation in human NCI-H1975 cells preincubated for 1 hr followed by stimulation with EGF for 8 mins by electrochemiluminesc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEpidermal growth factor receptor(Human)
Charles River Laboratories

Curated by ChEMBL
LigandPNGBDBM50498976(CHEMBL3736183)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR phosphorylation in human NCI-H292 cells preincubated for 1 hr followed by stimulation with EGF for 8 mins by electrochemiluminesce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)