BDBM50499401 CHEMBL3735770

SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3C[C@@H](SCCCCCC(=O)Nc3cccc(c3)C(=O)N(O)CCCC)[C@@]21[H]

InChI Key InChIKey=JVMAHNUVIQGWMZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50499401   

TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50: 4.37E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed