BDBM50500310 CHEMBL3747647

SMILES Cc1cc2c(cccc2n1-c1nc2CCNCc2c(NCc2ccccc2)n1)C(N)=O

InChI Key InChIKey=JYYSDZNVELJCGG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50500310   

TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500310(CHEMBL3747647)
Affinity DataIC50: 40nMAssay Description:Inhibition of human p97 ATPase incubated for 15 mins by ADP Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500310(CHEMBL3747647)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as accumulation of K48 poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500310(CHEMBL3747647)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as reduction in p62 protein incubated for 6 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
Cleave Biosciences

Curated by ChEMBL
LigandPNGBDBM50500310(CHEMBL3747647)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of p97 ATPase in human A549 cells assessed as accumulation of CHOP poly-ubiquitinated proteins incubated for 6 hrs by immunofluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed