BDBM50502281 CHEMBL4529328

SMILES CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(cc1)\N=N\c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI Key InChIKey=GYDIODUAPVHOIG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50502281   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50502281(CHEMBL4529328)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant human SIRT2 defatty-acylase activity using SFP3 as substrate measured at 5 mins interval for 60 mins in presence of NAD+ by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50502281(CHEMBL4529328)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged SIRT1 (Met1 to Ser747 residues) demyristoylase activity expressed in Escherichia coli using p5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50502281(CHEMBL4529328)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human SIRT2 deacylation activity using Fluor de Lys Sirt2 as substrate measured at 5 mins interval for 30 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50502281(CHEMBL4529328)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant human SIRT2 demyristoylase activity using p53(Myr)-AMC as substrate measured after 3 hrs in presence of NAD+ and trypsin by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50502281(CHEMBL4529328)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged SIRT1 (Met1 to Ser747 residues) defatty-acylase activity expressed in Escherichia coli using S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed