BDBM50502342 CHEMBL4470945

SMILES O=C(N[C@H]1CCc2ccccc2NC1=O)c1n[nH]c(Cc2ccccc2)n1

InChI Key InChIKey=BHGLFKVEJPVPQY-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502342   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50502342(CHEMBL4470945)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/17/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50502342(CHEMBL4470945)Copy SMILESCopy InChI

Affinity DataIC50: 63nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/17/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL