BDBM50502733 CHEMBL4446699::US11479539, Compound 80

SMILES CO[C@]1(c2ncc(F)cc2-c2ccns2)C=C(C#N)C(=O)C(C)(C)C1

InChI Key InChIKey=AMJALMCHLCZRNN-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502733   

TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502733BDBM50502733(CHEMBL4446699 | US11479539, Compound 80)
Affinity DataEC50:  2nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
Targethek293 luciferase(HIV-1)
Medimmune

US Patent
LigandChemical structure of BindingDB Monomer ID 50502733BDBM50502733(CHEMBL4446699 | US11479539, Compound 80)
Affinity DataEC50:  2nMAssay Description:Purpose of the AssayThe purpose of this assay is to identify small molecule inhibitors of Keap1, preventing Keap1 binding to Nrf2, and thus activatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent