BDBM50502984 CHEMBL4584518

SMILES Cc1ccn2c(c1)nc(CSc1nnc(NC(=O)Nc3ccc(C)c(F)c3)s1)cc2=O

InChI Key InChIKey=JFCYWHYNRRJMQL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50502984   

LigandPNGBDBM50502984(CHEMBL4584518)
Affinity DataIC50: 69nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM50502984(CHEMBL4584518)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of human full length TRKA expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Zoetis

Curated by ChEMBL
LigandPNGBDBM50502984(CHEMBL4584518)
Affinity DataIC50: 4.62E+3nMAssay Description:Inhibition of human full length TRKB expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed