BDBM50503692 CHEMBL4437833
SMILES Cc1ncc(cn1)-c1ccc(cc1)C(C(=O)NO)c1ccccc1F
InChI Key InChIKey=SFXMVIQZYOMYOF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50503692
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Charles River Discovery (Previously Biofocus)
Curated by ChEMBL
Charles River Discovery (Previously Biofocus)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human full length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Ac-Arg-Gly-Lys(Ac) as substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of recombinant human HDAC6 expressed in HEK293 cells using Lys-Ac-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Charles River Discovery (Previously Biofocus)
Curated by ChEMBL
Charles River Discovery (Previously Biofocus)
Curated by ChEMBL
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substr...More data for this Ligand-Target Pair
Affinity DataKd: 80nMAssay Description:Binding affinity to HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substrate measure...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of HDAC4 catalytic domain (648 to 1057 residues) (unknown origin) using Boc-Lys-TFA as substrate measured after 60 mins by fluorescence as...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human C-terminal His-tagged HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using Boc-...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human full length C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using Lys-Ac-AMC as substrate mea...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 insect cells using Boc-Lys-TFA as substra...More data for this Ligand-Target Pair