BDBM50504714 CHEMBL4460301
SMILES Cc1cc2ncn(CC(C(O)=O)P(O)(O)=O)c2cc1C
InChI Key InChIKey=KLWGAEZHEYXBGT-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50504714
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
University of Iowa
Curated by ChEMBL
University of Iowa
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant rat FTase expressed in Escherichia coli using dansyl-GCVLS as substrate after 1.5 hrs by spectrofluorimetric analysisMore data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta(Rattus norvegicus)
University of Iowa
Curated by ChEMBL
University of Iowa
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of FDPS (unknown origin) using [14C] IPP and GPP as substrate preincubated for 10 mins followed by substrate addition and measured after 3...More data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-2 subunit alpha(Rattus norvegicus)
University of Iowa
Curated by ChEMBL
University of Iowa
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant rat RabGGTase expressed in Escherichia coli using Rab7 as substrate and [3H]geranylgeranyl pyrophosphate after 20 mins by l...More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University of Iowa
Curated by ChEMBL
University of Iowa
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GGDPS (unknown origin) using [14C] IPP and FPP as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair