BDBM50505833 CHEMBL4564777

SMILES CC(=O)Nc1ccc2c(ccnc2c1O)-c1cccs1

InChI Key InChIKey=XPLAFVDOIZNULQ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505833   

TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505833(CHEMBL4564777)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505833(CHEMBL4564777)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505833(CHEMBL4564777)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of topoisomerase 2alpha dependent TCF transcription in human SW620 organoids transduced with TOPflash luminescent reporter after 72 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505833(CHEMBL4564777)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with EcadPro-RFP reporter assessed as reversion of epithelial-mesenchymal tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed