BDBM50505835 CHEMBL4463643

SMILES CC(=O)Nc1ccc2c(ccnc2c1O)-c1cc2ccccc2o1

InChI Key InChIKey=BDFCSPQYHXGQSV-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505835   

TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505835(CHEMBL4463643)
Affinity DataIC50: 200nMAssay Description:Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505835(CHEMBL4463643)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of topoisomerase 2alpha dependent TCF transcription in human SW620 organoids transduced with TOPflash luminescent reporter after 72 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505835(CHEMBL4463643)
Affinity DataEC50:  3.50E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505835(CHEMBL4463643)
Affinity DataEC50:  5.40E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with EcadPro-RFP reporter assessed as reversion of epithelial-mesenchymal tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed